Mekong Lowlands and Central Plains is a region in Cambodia and includes the following provinces: Kampong Cham, Kampong Chhnang, Kampong Thom, Kandal, Kratie to the west of the Mekong, Prey Veng, Svay Rieng, Phnom Penh and Takeo.

The capital of Phnom Penh is located at the confluence of the Mekong and the Tonle Sap rivers. Phnom Penh International Airport (IATA: PNH | ICAO: VDPP) is the largest airport in Cambodia, located 7 km west of the city.

Kampong Cham is the third largest city in Cambodia and the capital of the province with the same name. This city has yet to be heavily touristed like Phnom Penh or Siem Reap. It carries with it plenty of colonial French charm, and has a genuine "wild west" feel to it. Most travellers who do find themselves in Kampong Cham are in transit to elsewhere in the country, but those that choose to spend at least a couple of days in the provincial capital will enjoy the laid back atmosphere and quaint charm. The highway between Kampong Cham city and the capital, Phnom Penh, is one of the best in the country, being paved and divided. It runs along the Mekong, and buses frequent this route daily, so you should have no trouble getting between the two cities.

Kompong Thom is the capital of Kampong Thom Province in Cambodia. It's situated about half-way between Phnom Penh and Siem Reap and thus most travellers will only rush through on their transfer between these two major attractions. Nevertheless it is a pleasant and relaxed place and a good starting point for exploring the countryside and the temples of Sambor Prei Kuk